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Sepsis

Transcript: Severe sepsis: sepsis complicated by organ dysfunction Septic shock: Sepsis complicated by a high lactate level or by shock that doesn't improve after fluid resuscitation Bacteremia: Presence of viable bacteria in the blood Control/Prevention The most effective way to decrease the incidence of sepsis is to prevent the infection from occurring in the first place. Proper aseptic technique, cleansing wounds and hand washing decreases chances of sepsis. Definition: "a potentially fatal whole-body inflammation caused by severe infection" 2 of the following symptoms must be exhibited to be diagnosed septic: Fever above 38.5 C or below 35 C Heart rate greater than 90 beats per minute Respiratory rate greater than 20 breaths per minute Probable or confirmed infection Symptoms: Primarily sepsis is caused by infection from the lungs, abdomen and urinary tract. Almost 50% of septic cases start as an infection of the lungs. Infective agents are usually bacteria but may be fungi and viruses. Canada sees approximately 9300 deaths annually from sepsis and over 30,000 cases each year diagnosed. In developing world sepsis account for 60-80% of childhood deaths. It can be caused by anything from a scraped knee to appendicitis. Sepsis Treatment/Cure Diagnosis would be upgraded to severe sepsis if one of the following symptoms. This would indicate an organ may be failing. Significantly decreased urine output Abrupt change in mental status Decrease in platelet count Difficulty breathing Abnormal heart pumping function Abdominal pain This disease is extremely serious and may result in death if not treated promptly. In those that survive there may be long term effects if any organs have been damaged by the disease. Causes: People with decreased immunity such as HIV/AIDS, cancer Very young babies The elderly People who have been hospitalized recently Diabetics Those at greater risk: Management of sepsis includes IV fluids, antibiotics, surgical drainage of infected fluid collections and support for organ dysfunction. Systemic Inflammatory Response System (SIRS) Diagnosis: Although sepsis can not be transmitted from person to person vaccinations are important. The "Flu Shot" can decrease the likelihood of lung infection. IV drug users are at greater risk as they are possibly introducing bacteria at time of injection. Types: Sepsis is otherwise known as: Prompt diagnosis is key in the treatment of sepsis. Within the first 3 hours of suspected sepsis diagnostic studies should be performed. These include: measurement of serum lactate obtain blood cultures (this ensures that the appropriate antibiotic is being used as long as it does not prolong intervention greater than 45 minutes) Broad spectrum antibiotics are recommended within one hour of making a diagnosis of severe sepsis. For every one hour delay in the administration of antibiotics there is a 6% rise in the mortality rate.

Sepsis

Transcript: Rapid change in breathing and mental status. Fever, chills, low body temperature, and decreasing in urination,nausea, diarrhea When find out should be immediately hospitalized Causes and Symptoms of Sepsis Conclusion My partner and I found Sepsis interesting because learning about a deadly disease could spread awareness throughout the class. We felt the most useful source of information was the internet. More specifically Sepsis Alliance. Something more that we would want to see the process of being diagnosed and the thought the journey through the disease. We feel that our strengths of this paper are the amount of information we have gathered. We also feel our weakness of the paper is not knowing how the person is really feeling when going through this hard part in their life. We have enjoyed learning about this deadly disease and hope to meet a survivor of this deadly disease in our future. Cures, Costs, and Preventions of Sepsis Summary and Background Information on Sepsis This Picture shows how the bacteria invades the body. People whose immune systems are weak due to illnesses such as HIV/AIDS Cancer or use of drugs that aggravate the immune system. Those who have had transplanted organs are at higher risk. Very young babies. The elderly, particularly if they have other health problems. People who have recently been hospitalized, People that have had invasive medical procedure, and lastly people with diabetes are more likely to get this deadly disease than others. Sepsis Bella Moynihan and Anna Gregory Science/1 November 18, 2013 Sepsis is a serious medical condition that is occurs when your immune system has a severe negative response to a disease. It takes place in your circulatory system. It is a potentially fatal disease Affects Sepsis has on the Human Body Medication goes through tubes to ensure it gets into the bloodstream quickly. Medication when first injected is a broad spectrum medication to kill of the most common bacteria and then they go from there on more specific medication. An IV is injected to regulate fluids because blood pressure is low. Vasopessor medication is then given to constrict the blood vessels due to how low the blood pressure if the blood pressure is still low . You can't fully avoid Sepsis but you can build your immune system by eating well and washing your hands are two of many was to boost your immune system Cures, Costs, and Preventions Treatment of Sepsis is very expensive because you have to stay in a long term hospital. curable disease, but even after being cured, you still could die antibiotics , vasopressors Depending on your condition, you may need a machine to help you breath. You may also need to have surgery in severe cases. Vasopressors constrict blood vessels and help to increase blood pressure. Depending on your condition, you may need a machine to help you breath. Diagnosis and Treatments for Sepsis The most common organ system that is affected is the cardiovascular system. When Sepsis attacks the body most of your organs go into Septic Shock and then your body can't preform. Unfortunately 37% of people die from Septic Shock It is a life-threatening infection that can worsen very fast. Sepsis can also be caused by bacteria that enters the body. You can get it by even just getting a scraped knee or a infected cuticle. People who get Sepsis may have a disruption in their immune system. Some people survive this disease even after having an episode. You are more vulnerable to disease If you have records of chronic disease you may have permanent organ damage. In some cases you can lose limbs,organs, or kidney failure Fortunately there are 1.4 million survivors of Sepsis in the United States. You must have two of the following symptoms in order to have the diagnosis. You need to have more than 90 heartbeats per minute, more than 20 breaths per minute. A fever over 101.3 degrees or a fever under 95 degrees Fahrenheit. Rapid breathing change and change in mental status such as reduced alertness are the first signs of Sepsis Sepsis can lead to organ dysfunction which can kill you. Not only can bacteria start this disease, but fungi, viruses, and parasites in the blood, urinary tract, lungs, skin, and other tissue can. Immune chemicals are released into the blood and fight the infection. This leads to blood clots and leaky vessels. To prevent Sepsis from occurring, you can wash your hands before preparing food, eating, after using the bathroom, or using public transportation. If you don't do these things, it may lead to bacteria entering your body. Make sure to exercise and get enough sleep. Treatment of Sepsis is very expensive because you have to stay in a long term hospital. Causes and Symptoms of Sepsis This is an example of a target of Sepsis Conclusion This is one way that doctors treat Sepsis This is an image of the bacteria that infects the body when you have Sepsis. This is an IV which the medicine is brought to the body though quickly

Sepsis

Transcript: Amar Javaid Systemic response to infection, characterised by an exaggerated inflammatory response and widespread tissue injury Sepsis SSI + Infection (20% mortality) Severe Sepsis SSI + Infecton + Organ dysfunction (40% Mortality) Septic Shock SSI + Infection + Organ dysfunction + Hypotension (60% Mortality) Managing Sepsis Sepsis Six If hypotensive and/or lactate >4 administer 30ml/kg crystalloid Broad spectrum Abx within 3 hours of ED admission and within 1 hour of recognition on ward Oxygen Fluid Resuscitation Blood Cultures Antibiotics Measure Hb and Lactate Monitor UO DO2 = CO x CaO2 DO2 = (SV x HR) x ((Hb x SaO2 x 1.34) + (PaO2 x 0.0225)) HR 110 BP 105/76 Temp 38.5 RR 18 Sats 92% on RA UO has tailed off 'Just doesn't look right' JB is now day 2 post op Uncomplicated recovery so far Had shot of intra-op Abx Allowed clear fluids orally Being NG fed (just started) What do you do? A - patent - talking, slightly confused B - Decreased A/E bibasally, no added sounds, RR 22, Sats 100% on 15L NRB C - HR 118, CRT ~ 2-3 secs, BP 100/60 D - E3, V4, M6 - 13/15 E - Abdomen tender, wound dressed, some guarding, no rebound tenderness, minimal BS BM 6.4 So what next? You give some fluid ABG on 15L NRB - pH 7.2, pO2 44, pCO2 4.6, Lac 1.9, Bic 17, BE -4.2 CXR - Bibasal atelectasis, no consolidation Does the patient have SSI? Temp 38.5 HR 118 Altered mental state RR 22 You make your SHO aware Diligently do the 'Sepsis Six' Take cultures and send bloods Prescribe Abx Tell the nurse you will r/v pt again with bloods You return slightly bitter after prescribing 20 warfarins, re-writing 8 drug charts and blindly prescribing more 'maintenance fluids' for what seems like all the surgical patients in the hospital, pushing half of them into pulmonary oedema and the other half into hyperchloraemic metabolic acidosis because you still haven't discovered balanced crystalloids; this on top of the 12 elective clerkings (8 of whom were in hospital at 2pm) Now he really doesn't look right Turns out nurse has been busy on her break, didn't get a chance to administer the Abx you prescribed Talking but you can't understand him Temp 39.2, HR 126, RR 28, BP 88/64 sats 94% on 15L NRB Repeat ABG - pH 7.15, pO2 35, pCO2 3.8, Lac 4.4, Bic 11, BE -8.4 Bloods - WCC 24, Hb 11.2, Plt 89, CRP 542, Na 144, K 5.9, Ur 14, CR 255 Is this sepsis/severe sepsis/septic shock? You give bolus of fluid 30mls/kg Little response UO has been 10mls/hr for last 3 hours What now? (Apart from hiding in the store room and crying whilst resisting the urge to punch the nurse in her face on your way out) You give Abx yourself Bleep your SHO and Reg who are both scrubbed with a ruptured AAA in theatre with your consultant Who do you call now? Critical Care arrive Confirm septic shock Punch the nurse and you for not giving Abx earlier Move the patient to HDU then ICU Insert a CVC and start NA Able to maintain MAP>65 but NA climbing Start Hydrocortisone 50mg QDS CVVHF for acidosis, AKI with hyperkalaemia and sepsis Pt develops ARDS --> Intubated and ventilated CT confirms anastamotic breakdown -->theatre He has his ileostomy refashioned Develops full blown ARDS Has a tracheostomy inserted at day 7 Has managed established NG feeds by day 10 with the help of some prokinetics IV Abx for 14/7 Develops some ICU psychosis requiring clonidine Takes a further 2 weeks before he can be weaned off the ventilator and put on to Drager CPAP and stepped down to HDU He is eventually discharged home 2 months after admission for elective surgery However unable to work as labourer at building site because of residual weakness In these times of austerity his employer sacks him Used to sing but since tracheostomy rubbish voice He becomes depressed and turns to heroin His girlfriend SG dumps him Now he is a long-term financial burden on the economy and the NHS with his thieving, abscesses, endocarditis, valve replacement and mandatory methadone rehabilitation programme All because YOU didn't give Abx Any Questions? You are the 'front-line' in fighting sepsis Fluids and Abx SAVE LIVES Please learn to administer Abx youself If a patient has SSI --> Sepsis Six If Severe Sepsis or Septic Shock --> Early involvement of Critical Care Now go out and save lives (Ok from tomorrow when you're back) What is Sepsis? You're oncall surgical FY1 Bleeped by ward Patient has EWS 4 What information would you like? Signs of Organ Dysfunction 28 yr old male - JB Normally fit & well Stabbed to abdomen --> Laparotomy --> bowel resection with ileostomy Post-op - reversal of ileostomy Summary Temp - <36 or >38 HR >90 RR >20 or PaCO2 <4 kPa WCC - <4 or >12 Acutely altered mental state Hyperglycaemia in absence of diabetes Signs & Symptoms of Infection (SSI) Case Study Recognising Sepsis SEPSIS SBP <90 or MAP <70 UO <0.5ml/kg/hr Lactate >2 Unable to maintain SpO2>90% without O2 INR >1.5 Plts <100 Bilirubin >34 Creatinine >177

Sepsis

Transcript: The second T is for Tachycardia, heart rate > 90 bpm Central Venous Catheters Sepsis Perfusion Status A respiratory rate >20 breaths/minute Diagnosis: SIRS/Sepsis Criteria 3T's, 1W, Just Need 2 Though in hospital mortality decreased between 1979 and 2001... Management Estimates of the risk of dying of severe sepsis: Patient's age Underlying condition Various physiologic variables Diagnosis Supplemental Oxygen and Pulse oximetry Consider intubation and mechanical ventilation F/U respiratory interventions with ABG and CXR Diagnosis Prognosis The first T is for Temperature Prognosis The SIRS Criteria: 3T's and the 1W, Just Need 2 Diagnosis of sepsis lies on identification of the 4 cardinal signs of Severe Inflammatory Response Syndrome and suspected infection 30 Day Mortality of Patient by Septic Subtype Severe Sepsis: 20-35% Septic Shock: 40-60% Fever of temperature >38°C OR Hypothermia (<36°C) Prognosis: APACHE II Stratification Management and Therapy Priorities: 1. Correct Physiologic Abnormalities like hypoxemia or hypovolemia 2. Identifying and Treating the infection Central venous catheters can be used for: infusing medications, blood products, and fluids drawing blood central venous pressure and central venous oxygenation monitoring Preexisting illness: Death is significantly during the third to fifth decades. Respiratory Stabilization No preexisting morbidity: Fatality rate remains <10% until the fourth decade of life It gradually increases to exceed 35% in the very elderly The W stands for White Blood Cell Count Leukocytosis >12,000/uL or Leukopenia <4,000/uL The third T is for Tachypnea Assess for hypotension using blood pressure Check for other signs of hypoperfusion such as skin temperature abnormality, altered mentation, restlessness, oliguria/anuria, or lactic acidosis Aspects of hypoperfusion may be patient specific Mortality rates remain at about 15-20% The key point is that sepsis is a fatal disease and it is our job as physicians and healthcare providers to be ever vigilant in this fatal illness

Sepsis

Transcript: Sepsis -therapy may be needed including large amounts of oxygen and intravenous fluids How do you treat Sepsis? sepsis affects the very elderly or the young, and patients just out of surgery How do you acquire Sepsis? -Antibiotics are given even before the infectious agent is identified Urine- checked for signs of bacteria. Wound secretions-testing a sample of the wound's secretions can help show what type of antibiotic might work best Respiratory secretions- If you are coughing up mucus, it may be tested to determine what type of germ is causing the infection. Chills Confusion or delirium Fever or low body temperature (hypothermia) Light-headedness due to low blood pressure Rapid heartbeat Shaking Skin rash Warm skin blood flow to vital organs, such as your brain, heart and kidneys, becomes impaired. Sepsis can also cause blood clots to form in your organs and in your arms, legs, fingers and toes — leading to varying degrees of organ failure and tissue death (gangrene) -the presence of pathogenic organisms or their toxins in the blood and tissues -toxic response to an infection Blood test -Evidence of infection -Clotting problems -Abnormal liver or kidney function -Impaired oxygen availability -Electrolyte imbalances White blood cells -surgery may be an necessary to remove sources of infection All types of infections can lead to sepsis but the most common ones are -Pneumonia -Abdominal infection -Kidney infection -Bloodstream infection (bacteremia) -Vasopressor medication are given next, which help constrict blood vessels and increase blood pressure -drugs that modify the immune system What is Sepsis? How to test if you have sepsis What part of your blood is infected? if the blood test doesnt work then you can get certain areas tested like...

Office PowerPoint Template Guide

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