Sepsis
Transcript: Amar Javaid Systemic response to infection, characterised by an exaggerated inflammatory response and widespread tissue injury Sepsis SSI + Infection (20% mortality) Severe Sepsis SSI + Infecton + Organ dysfunction (40% Mortality) Septic Shock SSI + Infection + Organ dysfunction + Hypotension (60% Mortality) Managing Sepsis Sepsis Six If hypotensive and/or lactate >4 administer 30ml/kg crystalloid Broad spectrum Abx within 3 hours of ED admission and within 1 hour of recognition on ward Oxygen Fluid Resuscitation Blood Cultures Antibiotics Measure Hb and Lactate Monitor UO DO2 = CO x CaO2 DO2 = (SV x HR) x ((Hb x SaO2 x 1.34) + (PaO2 x 0.0225)) HR 110 BP 105/76 Temp 38.5 RR 18 Sats 92% on RA UO has tailed off 'Just doesn't look right' JB is now day 2 post op Uncomplicated recovery so far Had shot of intra-op Abx Allowed clear fluids orally Being NG fed (just started) What do you do? A - patent - talking, slightly confused B - Decreased A/E bibasally, no added sounds, RR 22, Sats 100% on 15L NRB C - HR 118, CRT ~ 2-3 secs, BP 100/60 D - E3, V4, M6 - 13/15 E - Abdomen tender, wound dressed, some guarding, no rebound tenderness, minimal BS BM 6.4 So what next? You give some fluid ABG on 15L NRB - pH 7.2, pO2 44, pCO2 4.6, Lac 1.9, Bic 17, BE -4.2 CXR - Bibasal atelectasis, no consolidation Does the patient have SSI? Temp 38.5 HR 118 Altered mental state RR 22 You make your SHO aware Diligently do the 'Sepsis Six' Take cultures and send bloods Prescribe Abx Tell the nurse you will r/v pt again with bloods You return slightly bitter after prescribing 20 warfarins, re-writing 8 drug charts and blindly prescribing more 'maintenance fluids' for what seems like all the surgical patients in the hospital, pushing half of them into pulmonary oedema and the other half into hyperchloraemic metabolic acidosis because you still haven't discovered balanced crystalloids; this on top of the 12 elective clerkings (8 of whom were in hospital at 2pm) Now he really doesn't look right Turns out nurse has been busy on her break, didn't get a chance to administer the Abx you prescribed Talking but you can't understand him Temp 39.2, HR 126, RR 28, BP 88/64 sats 94% on 15L NRB Repeat ABG - pH 7.15, pO2 35, pCO2 3.8, Lac 4.4, Bic 11, BE -8.4 Bloods - WCC 24, Hb 11.2, Plt 89, CRP 542, Na 144, K 5.9, Ur 14, CR 255 Is this sepsis/severe sepsis/septic shock? You give bolus of fluid 30mls/kg Little response UO has been 10mls/hr for last 3 hours What now? (Apart from hiding in the store room and crying whilst resisting the urge to punch the nurse in her face on your way out) You give Abx yourself Bleep your SHO and Reg who are both scrubbed with a ruptured AAA in theatre with your consultant Who do you call now? Critical Care arrive Confirm septic shock Punch the nurse and you for not giving Abx earlier Move the patient to HDU then ICU Insert a CVC and start NA Able to maintain MAP>65 but NA climbing Start Hydrocortisone 50mg QDS CVVHF for acidosis, AKI with hyperkalaemia and sepsis Pt develops ARDS --> Intubated and ventilated CT confirms anastamotic breakdown -->theatre He has his ileostomy refashioned Develops full blown ARDS Has a tracheostomy inserted at day 7 Has managed established NG feeds by day 10 with the help of some prokinetics IV Abx for 14/7 Develops some ICU psychosis requiring clonidine Takes a further 2 weeks before he can be weaned off the ventilator and put on to Drager CPAP and stepped down to HDU He is eventually discharged home 2 months after admission for elective surgery However unable to work as labourer at building site because of residual weakness In these times of austerity his employer sacks him Used to sing but since tracheostomy rubbish voice He becomes depressed and turns to heroin His girlfriend SG dumps him Now he is a long-term financial burden on the economy and the NHS with his thieving, abscesses, endocarditis, valve replacement and mandatory methadone rehabilitation programme All because YOU didn't give Abx Any Questions? You are the 'front-line' in fighting sepsis Fluids and Abx SAVE LIVES Please learn to administer Abx youself If a patient has SSI --> Sepsis Six If Severe Sepsis or Septic Shock --> Early involvement of Critical Care Now go out and save lives (Ok from tomorrow when you're back) What is Sepsis? You're oncall surgical FY1 Bleeped by ward Patient has EWS 4 What information would you like? Signs of Organ Dysfunction 28 yr old male - JB Normally fit & well Stabbed to abdomen --> Laparotomy --> bowel resection with ileostomy Post-op - reversal of ileostomy Summary Temp - <36 or >38 HR >90 RR >20 or PaCO2 <4 kPa WCC - <4 or >12 Acutely altered mental state Hyperglycaemia in absence of diabetes Signs & Symptoms of Infection (SSI) Case Study Recognising Sepsis SEPSIS SBP <90 or MAP <70 UO <0.5ml/kg/hr Lactate >2 Unable to maintain SpO2>90% without O2 INR >1.5 Plts <100 Bilirubin >34 Creatinine >177