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medicinal chemistry

Transcript: is located at: 601 S. Morgan St. Chicago, IL 60607 4-Bedroom Apartment for 4: $9,398 pharmaceutical chemistry Medical Biotechnology MS: $3,449 UIC's Campus 12 Credit Hours: $5,441 Commons North (CMN) aka: Single Room Style (3–4 Residents) : $11,536 Single Room Style (5–6 Residents) : $11,350 your Ph.D. two years of post-doctoral experience. Degree Requirements General Information: (312) 996-4350 2-Bedroom Apartment for 2: $9,572 University of Illinois at Chicago By: Jordan Nichols can also be associated with: virtual walking tour that introduces the modernist architecture Office of Admissions and Records (MC 018): University of Illinois at Chicago Box 5220 Chicago, Illinois 60680-5220 Required Core Courses: GCLS 501 •MDCH 561 •four hours of MDCH 592 •plus a minimum of 6 additional hours of required concentration and elective courses. GPA: at least 3.00 (A=4.00) for the final 60 semester (90 quarter) hours of baccalaureate study. biomedicinal chemistry To become a medicinal chemist you must recieve... 4. Assessment Single Room Style: $10,826 General Fee: $425 Service Fee: $314 Student-Student Fee: $3 Sustainability Fee: $4 Health Service Fee: $88 Estimated Health Insurance Fee: $401 Estimated CTA U Pass Fee: $109 Required Concentration Courses: •Analytical and Chemical Toxicology – MDCH 412, 562, 571 •Biomedicinal Chemistry – GCLS 502; MDCH 412 •Computational Medicinal Chemistry – MDCH 572 •Structural Biology – BCHE(PMPG) 513 •Synthetic Medicinal Chemistry – MDCH 560, 562, 571. 1. Graduate Tuition Size: about 240 acres; Tuition and Fees Room and Board: Tests Required: GRE general and have at least... Academic Facilities Maintenance Fund Assessment: $309 3. Graduate Fees College that offers this major is: Campus Attractions Medicinal Chemistry: 16,806 students enrolled Medicinal Chemistry Letters of Recommendation: Three required •Baccalaureate Field: Pharmacy, chemistry, or the biological sciences. Prior academic work should include a year each of biology or biochemistry and organic chemistry. Admission Requirements Administration/Operations: 312-996-7000 2. Graduate Tuition Differentials The Historic Netsch Campus organic chemistry TOTAL COST: $10,743 Contact us Commons South (CMS) toxicologists Library and Information Technology Assessment: $200 Thomas Beckham Hall (TBH) & Marie Robinson Hall (MRH) the application of chemical research techniques to the synthesis of pharmaceuticals to develop and create drugs for human usages Studio Apartment for 1: $11,318

Medicinal Chemistry

Transcript: Medicinal Chemistry Education Classes like: anatomy, biochemistry, pharmacology, microbiology, pathology, etc. Bachelor's Degree in pharmacology, organic chemistry, or medicinal chemistry. To develop your own experiments, you must get a PhD. Where to work Universities Little supervisions, must write grants for funding, can lead teams of technicians and undergrad assistants. Government Agencies Carry out clinical trials, conduct research on human test subjects, can work for places like the FDA. Private Industries Limited freedom to choose experiments, develop pharmaceutical drugs, companies place strong emphasis on getting products developed. Work Environment Most medicinal chemists work in offices or labs. Spend their time studying data and reports or conducting research and experiments. Many write reports in findings that may be put out to the public. May work on their own research and experiments or in a group. Medicinal chemists produce, formulate, and analyze new drug compounds. Also work on improving already existing drugs. Job Outlook: For now, job growth is very slow, but expected to increase within several years as need for research and medicine increases. Salary: Average salary is about $76,000.

Medicinal Chemistry

Transcript: Because of the economy and government health care reform regulations medicinal chemist in today's market is mixed.Theres allot of changes going on causing companies to decrease the size of their research labs.Even though some industries are downsizing some government agencies are looking for chemist to fill non laboratory chemistry positions. This profession fits me because I like coming up with new things and I like communicating with other to produce something that not only benefits us but benefits other people. This also fits my education because I actually would like to get majors in chemistry to either teach it or get a job that involves chemistry. Bachelor Degree at the very least. Most have earned a master's or doctoral degree. Bachelor of Science in chemistry or chemical engineering. Personal Characteristics Education They apply their chemistry training to new pharmaceutics and improve them.Most of the chemist work with other scientist such as biologist, toxicologist,pharmacologist, theoretical chemistry and many more. Together they come up with new techniques to apply and test in new drugs developing a effective environmentally means of production. Medicinal Chemistry Wages & Benefits Chemist must enjoy different activities and be determine in exploring new things or the unknown. Having a big imagination and persistence are two important qualities for this job. You must aldo be a social person and have good communication skills. Be a good writer and most important be a team player. Work Settings By:Karla Alfaro The benefits of this job is that you get to collaborate with different scientist and you gain more knowledge of the different drugs that are being produced. Also with the knowledge that you gain you can study to be another thing related to chemicals. Job Descriptions/Duties They offer many varieties of lab opportunities.Many chemist use this to research their skills to formulate,produce, and analyze new compounds. Each lab is unique not all study the same things. Some explore a compounds different mechanisms and some review drug applications. Employment Outlook Personal Assessment

Medicinal Chemistry

Transcript: Medicinal Chemistry Index Effects Kalkidan Bulbula There are five ways of administering a drug: 1. Injection a. Intravenous – veins b. Intramuscular – muscles c. Subcutaneous – under skin 2. Orally – mouth 3. Rectally – anus 4. By inhalation 5. Topically – on the skin (ointments, creams, …) Research 1. First the drug must be isolated or synthetized. 2. The drug is tested on animals. LD50 and ED50 are determined. 3. The drug moves to Clinical Trials a. Human Pharmacology – testing on small group of healthy volunteers for safety b. Therapeutic Exploratory – evaluates drug’s efficiency and side effects c. Confirmatory Stage – large-scale testing of drug 4. A local drug regulatory agency approves a medicine and decides whether it will be 5. OTC (over the counter) or on prescription only. Vocabulary Therapeutic window – the difference between the effective dose and lethal dose; also called therapeutic index Side effects – the undesired effects of drugs Ex: aspirin thins the blood (used as an anti-clotting agent to prevent a hearth attack) Morphium, the pain reliever, causes constipation. Tolerance – a person taking a drug often gets used to the active ingredient, so it takes larger and larger doses to obtain the drug’s desired effect. There is a danger that a body would create a physical addiction to a drug. For instance, an addiction to caffeine: if the addict does not get his/her coffee, he/she gets headaches. Another issue is that with increasing dose, the user is coming closer and closer to the lethal dose. Risk-to-benefit ratio – determines whether the side effects (risk) of the drug are acceptable in relation to its curing effects; for example, a drug curing baneful disease would be accepted despite high risks Methods of Administration LD50 is a lethal dose necessary to kill 50 percent of animal population. ED50 is an effective dose, one creating a noticeable effect in 50% of animal population. The ratio between LD50 and ED50 is called the Therapeutic Index. Therapeutic Index = LD50 / ED50 Therapeutic determines a safety of drug. If the therapeutic index of a drug is 10, a person would have to intake ten times more drug than the effective dose for the effects to be lethal. According to the therapeutic index, the researchers decide whether a dosage must be controlled. If TI is low, the dosage must be closely controlled. During testing, half of the patients receive a real drug and the other half similar-looking placebo. This determined whether the drug has a real effect or the pill only fooled body into healing. Drug or medicine is a substance that does one or more of the following: · Alters physiological state – consciousness, activity level, coordination · Alters incoming sensory experience · Alters mood or emotion The active ingredients in drugs and medicines can be isolated from a plants and animals or synthesized artificially. Drugs supposed to assist human body’s natural self-healing capabilities. Placebos are drugs containing no active ingredient, which “fool” the human body into healing.

Medicinal Chemistry

Transcript: Description Medicinal chemistry is using chemical research techniques to the synthesis of pharmaceuticals. Scientists were more concerned with the osolation of medicinal agents found in plants. Now a days scientists in medicinal chemistry are also concerned with the creation of synthetic drug compounds. This field is connected to ward drug discovery and development. Medicinal chemistry can lead to treatment of diseases wich I find very interesting. Training Most of the training required is a post doctoral fellowship which is taken in 2 years or more after recieving a PH.D in chemistry. The training for medicinal chemistry would be at a university level such as the university of Toronto Post Secondary In university the courses core subjects are biochemistry, anatomy and immunology which provides you with a understanding of the pharmacetical field. The main subject is organic chemistry where you work with organnic compounds. High School Required Courses Biology-as many biology courses as possible Chemistry- at least 4 semesters of chemistry at academic level Math- at least three years "In early 1975, the peroxide structure of yingzhaosu(2)27 inspired researchers that qinghaosu might also be a peroxide compound.The hypothesis was confirmed by simple qualitative analysis" Medicinal chemistry of bioactive natural products by- Xiaotain Liang, Wei-Shuo Fang pg 187 Bibliography http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1188&content_id=CTP_003395&use_sec=true&sec_url_var=region1&__uuid=6e6b911c-7348-4e9a-936e-d91a238a068e http://www.microbiotix.com/medicinalchemistry.htm the big picture http://medchem.rutgers.edu/mc501/pdfs/mc501_syll.pdf some techniques http://books.google.ca/books?id=yUGL1pdHfRcC&pg=PA187&dq=Medicinal+Chemistry+qualitative+analysis&hl=en&ei=K9i2TqTdE8nt0gGys4HJDQ&sa=X&oi=book_result&ct=result&resnum=6&ved=0CFAQ6AEwBQ#v=onepage&q=%20qualitative%20analysis&f=false book http://www.ehow.com/facts_4925339_courses-high-school-become-pharmacist.html courses in highschool http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1188&content_id=CTP_003395&use_sec=true&sec_url_var=region1&__uuid=f0e242bf-46f6-437a-beb9-eebb4af27429 training and what you would study http://joannekimkim.glogster.com/mc-description/ second picture Medicinal Chemistry http://www.microbiotix.com/medicinalchemistry.htm Some specific techniques include: thermodynamics, kinetics, isotope effects acids and bases substituent effects literature searching laboratory safety record keeping reaction mechanisms -additions -elimination -substitution -rearrangements -pericyclic reactions http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1188&content_id=CTP_003395&use_sec=true&sec_url_var=region1&__uuid=f0e242bf-46f6-437a-beb9-eebb4af27429 http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1188&content_id=CTP_003395&use_sec=true&sec_url_var=region1&__uuid=6e6b911c-7348-4e9a-936e-d91a238a068e http://medchem.rutgers.edu/mc501/pdfs/mc501_syll.pdf http://www.ehow.com/facts_4925339_courses-high-school-become-pharmacist.html

Medicinal Chemistry

Transcript: Structure based desgin Relies on Drug Design Conclusion What is medicinal Chemsitry? Focuses on drug design -Synthetic organic chemisty -Natural product chemistry Drug class: Statin Inhibits live enzyme HMG-CoA responsible for choloesterol production Prevention of cariovascular disease, treatment of dislypidemia Lipitor is here And one more thing... Medicinal Chemistry Focuses on synthesis of small organic molecules that activate or inhibit functions of molecules or protiens in the body, resuting in therputic effects on the person

MEDICINAL CHEMISTRY

Transcript: MEDICINAL CHEMISTRY TYPES OF DISEASES WATER BORNE DISEASES COMMON DISEASES 1. 2. 3. 4. 5. INSECT BORNE DISEASES 1. 2. 3. 4. 5. HERIDITARY DISEASES 1. 2. 3. 4. 5. AIR BORNE DISEASES 1. 2. 3. 4. 5.

Medicinal chemistry

Transcript: Medicinal chemistry The first at the level of Palestine and the Arab world. It is a multiple major in the fields of chemical knowledge, biology and pharmacy. Medicinal chemistry techniques are used in research to prepare new drugs, develop generic drugs, and extract natural products. ASMAA ISMAEEL HAIAT ALHADDAD What is medicinal chemistry? The main objective of the program is to find drug development at the global level. ‏Job opportunities 1)Teaching field: so that the graduate can teach chemistry, biology and public health. 2)Industry field: so that the graduate can work in pharmaceutical factories in addition to marketing medicines. 3)Work in natural products: extraction and synthesis; In addition to working in food additives and medical pharmacology. 4)Work in chemical analysis laboratories, pharmaceutical laboratories and forensic medicine. 5)Work in scientific research in multiple fields related to the subject. 6)Graduates can complete their medical studies in American and Canadian universities after taking the MCAT exam Acquired skills Search for medicines from natural sources, their composition, and study their effects on the human body and in the treatment of diseases. Drug manufacturing in the laboratory with the help of computerized chemistry Work with doctors to discover and develop medicines After graduation ‏Master and Ph.D. in Medical Chemistry, Chemistry, Biology and Pharmaceutical Sciences

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